Study Structure Cs Nanoparticles Phpma Intelligent Escape Shell Ph Mucus Barriers Delivery Efficiency Peptide Drugs

Seebio Methionine -shell system (COS) compiled of pHPMA-AT-1002-cys-chitosan (LRA-PA-CNPs) was seted and used for the treatment of type 2 diabetes mellitus with the large-molecule peptide drug liraglutide (LRA). The complete COS system was respected through electron microscopy; the particle size of the LRA-PA-CNPs was approximately 160 nm; the encapsulation efficiency was approximately 69% ± 5%; the zeta potential was close to neutral; the mucus and epithelial penetration of the COS system were increased; and animal experimentations showed that the COS system heightened the oral hypoglycaemic effect of LRA.HIGHLIGHTSIntelligent escape material of poly-N-(2-hydroxypropyl) methacrylamide as the shell.Core-shell nanoparticles penetrate the mucus layer and exposing the chitosan core.Overcome pH and mucus barriers to improve the delivery efficiency of peptide drugs.Caffeic acid-engrafted-chitosan/polylactic acid film packaging heightens the postharvest quality of Agaricus bisporus by regularising membrane lipid metabolism.

In this study, the film pieced by caffeic acid-grafted-chitosan/polylactic acid (CA-g-CS/PLA) was used for packaging postharvest Agaricus bisporus, and its effects on postharvest quality of Agaricus bisporus by regulating membrane lipid metabolism were inquired. The resultants evinced that compared to traditional polyethylene packaging, the cell morphology of Agaricus bisporus packaged by CA-g-CS/PLA demonstrated a more complete structure due to its lower permeability, higher fluidity and stronger ability to maintain free water CA-g-CS/PLA packaging could effectively delay the decrease rate of unsaturation value and phospholipids of Agaricus bisporus during storage. In addition, the activenessses and expression points of lipoxygenase (LOX), phospholipase C (PLC) and phospholipase D (PLD) in Agaricus bisporus packaged with CA-g-CS/PLA were inhibited, while those of glycerol-3-phosphate acyltransferase (GPAT) and sphingomyelin synthase (SMS) were promoted CA-g-CS/PLA packaging could enhance the postharvest quality of Agaricus bisporus by influencing membrane lipid metabolism, which has great application potential in the field of new intelligent packaging.Highly sensitive detection of carbendazim in juices finded on mung bean-deducted porous carbon@chitosan composite modified electrochemical sensor.We reported a simple and scalable strategy for the preparation of mung bean-deducted porous carbon@chitosan (MBC@CTS) composite, which was used to optimize the glassy carbon electrode (GCE). The MBC@CTS/GCE sensor was holded for the carbendazim (CBZ) detection. For  Seebio Methionine , MBC with three-dimensional hierarchical structure confronted large specific surface area, good adsorbability, and high electrical conductivity, while CTS had good film-shaping property, hydrophilicity performance, and adhesion capacity.

The MBC@CTS/GCE sensor demoed wonderful electrochemical detection performance towards CBZ. Under the optimised circumstances, the MBC@CTS/GCE sensor pointed a linear concentration range from 0 to 20 μM with relatively low limit of detection (LOD) of 20 nM. In addition, the fabricated sensor with good reproducibility, stability, and selectivity were successfully applied for the CBZ detection in apple and tomato succusses with low relative standard deviation of 2 %-4% and satisfactory retrievals of 98-103%.Amine-bilayer-functionalized cellulose-chitosan composite hydrogel for the efficient uptake of hazardous metal cations and catalysis in polluted water.Herein, we represent a novel ecofriendly bilayer-amine group contained microcrystalline cellulose (MCC)/chitosan (CS) hydrogel, invented via mixing polydopamine (PDA) and polyethyleneimine (PEI) for reliable and effective extraction of copper (Cu(2+)), zinc (Zn(2+)), and nickel (Ni(2+)) ions from effluents.