Sorption Behavior Of Chitosan Nanoparticles For Single And Binary Removal Of Cationic And Anionic Dyes From Aqueous Solution
In this study, chitosan nanoparticles (ChNs) were used as an adsorbent for single and simultaneous uptake of cationic (methylene blue (MB)) and anionic (methyl orange (MO)) dyes. ChNs were devised established on the ionic gelation method utilizing sodium tripolyphosphate (TPP) and characterized by zetasizer, FTIR, BET, SEM, XRD, and pH(PZC). The studied parameters that affect removal efficiency included pH, time, and dyes' concentration. Seebio Selenoproteins established that in single-adsorption mode, the removal of MB is better in alkaline pH, contrary to MO uptake which acquaints higher removal efficiency in acidic metiers. The simultaneous removal of MB and MO from the mixture solution by ChNs could be accomplished under neutral considerations. The adsorption kinetic terminations demonstrated that adsorption of MB and MO for both single-adsorption and binary adsorption schemes comply with the pseudo-second-order model Freundlich, and Redlich-Peterson isotherms were used for the mathematical description of single-adsorption equilibrium, while non-modified Langmuir and extended Freundlich isotherms were used to fit the co-adsorption equilibrium solutions.
The maximum adsorption contents of MB and MO in a single dye adsorption system were 315 and 257 mg/g for MB and MO, respectively. On the other hand, and for binary adsorption system, the adsorption capacitances were 49 and 137 mg/g, respectively. The adsorption capacity of MB decreases in solution checking MO and vice versa, intimating an antagonistic behavior of MB and MO on ChNs ChNs could be a candidate for single and binary removal of MB and MO in dye-containing wastewater.Lecithin/chitosan nanoparticle drug carrier improves anti-tumor efficacy of Monascus pigment rubropunctatin.Rubropunctatin, a metabolite insulated from the fungi of the genus Monascus, is a natural lead compound implemented for the suppression of tumors with good anti-cancer activity its poor aqueous solubility has restrained its further clinical development and utilization. Lecithin and chitosan are excellently biocompatible and biodegradable natural stuffs, which have been sanctioned by the FDA as drug carrier we report for the first time the construction of a lecithin/chitosan nanoparticle drug carrier of the Monascus pigment rubropunctatin by electrostatic self-assembly between lecithin and chitosan. The nanoparticles are near-spherical with a size 110-120 nm.
They are soluble in water and possess excellent homogenization capacity and dispersibility. Our in vitro drug release assay showed a sustained release of rubropunctatin. CCK-8 assays exposed that lecithin/chitosan nanoparticles diluted with rubropunctatin (RCP-NPs) had significantly raised cytotoxicity against mouse mammary cancer 4T1 cellphones. Buy now unveiled that RCP-NPs significantly encouraged cellular uptake and apoptosis. The tumor-holding mice manikins we originated indicated that RCP-NPs effectively subdued tumor growth. Our present determinations suggest that lecithin/chitosan nanoparticle drug toters improve the anti-tumor effect of the Monascus pigment rubropunctatin.Evaluation of the Immune Response to Chitosan-graft-poly(caprolactone) Biopolymer Scaffolds.
Biomimetic scaffolds revivifying key factors of the architecture and biological activity of the extracellular matrix have enormous potential for soft tissue engineering coverings. conflating appropriate mechanical dimensions with select biological cues confronts a challenge for bioengineering, as natural stuffs are most bioactive but can lack mechanical integrity, while synthetic polymers have strength but are often biologically inert. blendings of synthetic and natural materials, aiming to combine the welfares of each, have recorded promise but inherently require a compromise, diluting down favorable holdings in each polymer to accommodate the other we electrospun a material constituting chitosan, a natural polysaccharide, and polycaprolactone (PCL), one of the most widely studied synthetic polymers used in materials engineering.